Tin (IV) Etiopurpurin Dichloride: An Alternative To DHE?

Alan R. Morgan; Greta M. Garbo; Rick W. Keck; Steven H. Selman

doi:10.1117/12.942708

19 February 1988 Tin (IV) Etiopurpurin Dichloride: An Alternative To DHE?

Alan R. Morgan, Greta M. Garbo, Rick W. Keck, Steven H. Selman

Proceedings Volume 0847, New Directions in Photodynamic Therapy; (1988) https://doi.org/10.1117/12.942708
Event: Cambridge Symposium on Optics in Medicine and Visual Image Processing, 1987, San Diego, CA, United States

Abstract

Etiopurpurin is a photosensitizer developed from etioporphyrin I, which we have shown to be useful in PDT. Incorporation of tin into the macrocycle gives a derivative which appears to be more effective both in vitro and in vivo studies on tumor cytotoxicity, than the parent purpurin. In vitro studies have shown not only that tin etiopurpurin dichloride (SnET2C12) is an efficient photosensitizer, but also that its action spectrum appears to be consistent with both the absorption and emission spectra. In vivo studies include a histological examination of tumors treated with SnET2C12 and PDT which suggests that disruption of the tumor vasculature plays an active role in tumor necrosis; a twelve day dose response study to determine effective dose; a thirty day study to determine tumor regrowth; a study of normal tissue response to PDT and a study to determine the optimum time for phototherapy after injection of the drug. For these studies, the FANFT induced urothelial tumor line was used, although we have recently initiated studies on the R3327 AT rat anaplastic adenocarcinoma, a tumor which appears to be more resistant to PDT.

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Alan R. Morgan, Greta M. Garbo, Rick W. Keck, and Steven H. Selman "Tin (IV) Etiopurpurin Dichloride: An Alternative To DHE?", Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); https://doi.org/10.1117/12.942708

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