Silicon nanophotonic ring resonator sensors integrated in reaction tubes

C. Lerma Arce; A. Goes; E. Hallynck; P. Dubruel; K. Komorowska; S. Van Put; P. Bienstman

doi:10.1117/12.2003970

22 February 2013 Silicon nanophotonic ring resonator sensors integrated in reaction tubes

C. Lerma Arce, A. Goes, E. Hallynck, P. Dubruel, K. Komorowska, S. Van Put, P. Bienstman

Author Affiliations +

Proceedings Volume 8598, Bioinspired, Biointegrated, Bioengineered Photonic Devices; 85980I (2013) https://doi.org/10.1117/12.2003970
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Enzyme-linked immunosorbent assays (ELISA) are the most popular immunoassay techniques performed every day in hospitals and laboratories and they are used as a diagnostic tool in medicine and plant pathology, as well as a qualitycontrol check in various industries. However, complex labeling techniques are required to be able to perform the assay and non-specific binding and endpoint timing are difficult to optimize. These issues could be solved by label-free techniques such as silicon nanophotonic microring resonator sensors, but this platform requires complex microfluidics, which is very much removed from the daily practice in e.g. hospital labs, which still relies to a large degree on platforms like 96-well microtiter plates or reaction tubes. To address these issues, here, we propose the combination of a simple and compatible reaction tube platform with label free silicon-on-insulator (SOI) photonic biosensors, where the flow is through the sensor chip as opposed to over the chip as in more conventional approaches. This device allows real time detection and analysis. Its great flexibility and small footprint make it ideal for an easy handling in any laboratory.

Citation Download Citation

C. Lerma Arce, A. Goes, E. Hallynck, P. Dubruel, K. Komorowska, S. Van Put, and P. Bienstman "Silicon nanophotonic ring resonator sensors integrated in reaction tubes", Proc. SPIE 8598, Bioinspired, Biointegrated, Bioengineered Photonic Devices, 85980I (22 February 2013); https://doi.org/10.1117/12.2003970

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