Characterization of a bioinspired elastin-polypropylene fumarate material for vascular prostheses applications

Silvia Scaglione; Rossella Barenghi; Szabolcs Beke; Luca Ceseracciu; Ilaria Romano; Francesca Sbrana; Paola Stagnaro; Fernando Brandi; Massimo Vassalli

doi:10.1117/12.2021754

23 May 2013 Characterization of a bioinspired elastin-polypropylene fumarate material for vascular prostheses applications

Silvia Scaglione, Rossella Barenghi, Szabolcs Beke, Luca Ceseracciu, Ilaria Romano, Francesca Sbrana, Paola Stagnaro, Fernando Brandi, Massimo Vassalli

Author Affiliations +

Proceedings Volume 8792, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials; 87920H (2013) https://doi.org/10.1117/12.2021754
Event: SPIE Optical Metrology 2013, 2013, Munich, Germany

Abstract

Vascular prostheses are widely used devices fundamental to avoid the effect of life-threatening diseases and defects. Besides a long experience in the fabrication of biomaterials for vascular applications, many issues still remain unattended. In particular, obtaining a bio-resorbable and bio-active scaffold is a challenge of paramount importance. We present a novel application in which a promising biodegradable polymer, poly-propylene fumarate (PPF), is printed using three dimensional laser-induced cross-linking micromachining device. To enhance the biological role of the scaffold, a bio-inspired approach was taken, by coating the surface of the PPF with elastin, the main constituent of the innermost layer of natural veins and arteries.

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Silvia Scaglione, Rossella Barenghi, Szabolcs Beke, Luca Ceseracciu, Ilaria Romano, Francesca Sbrana, Paola Stagnaro, Fernando Brandi, and Massimo Vassalli "Characterization of a bioinspired elastin-polypropylene fumarate material for vascular prostheses applications", Proc. SPIE 8792, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials, 87920H (23 May 2013); https://doi.org/10.1117/12.2021754

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