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17 June 2013 Dual mode fibre bundle confocal endomicroscopy: combining reflectance and fluorescence imaging
Michael Hughes, Vasiliki Simaiaki, Tou Pin Chang, Guang-Zhong Yang
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Proceedings Volume 8797, Advanced Microscopy Techniques III; 879708 (2013) https://doi.org/10.1117/12.2032551
Event: European Conferences on Biomedical Optics, 2013, Munich, Germany
Abstract
Commercial endomicroscopes operate in fluorescence mode only and so require the application of contrast agents. As an alternative, we describe a fibre bundle confocal endomicroscope which acquires simultaneous and co-registered fluorescence and reflectance mode images. A combination of polarisation selection and refractive index matching is used to minimise back-reflections from the fibre bundle. We show preliminary results from the system using phantoms and tissue samples.
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Michael Hughes, Vasiliki Simaiaki, Tou Pin Chang, and Guang-Zhong Yang "Dual mode fibre bundle confocal endomicroscopy: combining reflectance and fluorescence imaging", Proc. SPIE 8797, Advanced Microscopy Techniques III, 879708 (17 June 2013); https://doi.org/10.1117/12.2032551
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KEYWORDS
Reflectivity
Luminescence
Endomicroscopy
Tissues
Confocal microscopy
Avalanche photodetectors
Tissue optics
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