A hp adaptive finite element algorithm for fluorescence molecular tomography based on SPN model

Hongbo Guo; Yuqing Hou; Xiaowei He; Jingjing Yu; Jingxing Cheng; Xin Pu

doi:10.1117/12.2033900

30 August 2013 A hp adaptive finite element algorithm for fluorescence molecular tomography based on SPN model

Hongbo Guo, Yuqing Hou, Xiaowei He, Jingjing Yu, Jingxing Cheng, Xin Pu

Proceedings Volume 8910, International Symposium on Photoelectronic Detection and Imaging 2013: Imaging Spectrometer Technologies and Applications; 891018 (2013) https://doi.org/10.1117/12.2033900
Event: ISPDI 2013 - Fifth International Symposium on Photoelectronic Detection and Imaging, 2013, Beijing, China

Abstract

The diffusion approximation of the radiative transport equation is the most widely used model in current researches on fluorescence molecular tomography (FMT), which is limited in some low or zero scattering regions. Recently, the simplified spherical harmonics equations (SP_N) model has attracted much attention in modeling the light propagation in small tissue geometries at visible and near-infrared wavelengths. In this paper, we report an efficient numerical method for FMT that combines the advantage of SP_N model and hp-FEM. For comparison purposes, hp-FEM and h-FEM are respectively applied in the reconstruction process with diffusion model and SPN model. Simulation experiments on a 3D digital mouse atlas are designed to evaluate the reconstruction methods in terms of the location and the reconstructed fluorescent yield. The experimental results demonstrate that hp-FEM with SPN model, yield more accurate results than h-FEM with DA model does. And the reconstructed results show the potential and feasibility of the proposed approach.

Citation Download Citation

Hongbo Guo, Yuqing Hou, Xiaowei He, Jingjing Yu, Jingxing Cheng, and Xin Pu "A hp adaptive finite element algorithm for fluorescence molecular tomography based on SPN model", Proc. SPIE 8910, International Symposium on Photoelectronic Detection and Imaging 2013: Imaging Spectrometer Technologies and Applications, 891018 (30 August 2013); https://doi.org/10.1117/12.2033900

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available