Paper
28 May 2014 Self-propelled, phage-based magnetoelastic biosentinels for detection of pathogens in liquid
Shin Horikawa, Ruiting Zhao, Yating Chai, Howard C. Wikle, Bryan A. Chin
Author Affiliations +
Abstract
This paper presents the concept of self-propelled magnetoelastic (ME) biosentinels that seek out and capture pathogenic bacteria in stagnant liquids. These biosentinels are composed of a free-standing, asymmetric-shaped ME resonator coated with a filamentous landscape phage that specifically binds with a pathogen of interest. When a time-varying magnetic pulse is applied, the ME biosentinels can be placed into mechanical resonance by magnetostriction. The resultant asymmetric vibration then generates a net force on the surroundings and hence generates autonomous motion in the liquid. As soon as the biosentinels find and bind with the target pathogen through the phage-based biomolecular recognition, a change in the biosentinel’s resonant frequency occurs, and thereby the presence of the target pathogen can be detected. In order to actuate the ME biosentinels into mechanical resonance of a desired mode, modal analysis using the three-dimensional finite element method was performed. In addition, the design of a magnetic chamber that can control the orientation and/or translation of a biosentinel is discussed.
© (2014) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Shin Horikawa, Ruiting Zhao, Yating Chai, Howard C. Wikle, and Bryan A. Chin "Self-propelled, phage-based magnetoelastic biosentinels for detection of pathogens in liquid", Proc. SPIE 9108, Sensing for Agriculture and Food Quality and Safety VI, 910805 (28 May 2014); https://doi.org/10.1117/12.2050533
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Cited by 1 scholarly publication.
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KEYWORDS
Magnetism

Pathogens

Liquids

Resonators

Target detection

Blood

Magnetic sensors

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