Reinforcement of osteogenesis with nanofabricated hydroxyapatite and GelMA nanocomposite

Zhaokai Meng; Chandani Chitrakar; Akhilesh K. Gaharwar; Vladislav V. Yakovlev

doi:10.1117/12.2080301

6 April 2015 Reinforcement of osteogenesis with nanofabricated hydroxyapatite and GelMA nanocomposite

Zhaokai Meng, Chandani Chitrakar, Akhilesh K. Gaharwar, Vladislav V. Yakovlev

Proceedings Volume 9303, Photonic Therapeutics and Diagnostics XI; 930340 (2015) https://doi.org/10.1117/12.2080301
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Every year in the United States approximately 1.5 million people are suffering from bone fractures. Current treatment solutions include surgeries and grafting process; however, it does not show any osteoconductive action, which is an essential character for biomaterials. The main objective of the reported studies is to develop a novel nanocomposite comprising of hydroxyapatite nanospheres (~40nm) and gelatin methacrylate to promote bone regeneration without any osteoinductive factors. To validate our hypothesis that chemical and mechanical properties of nanocomposite get enhanced, we employed various characterization techniques including Brillouin and Raman spectroscopies. The results imply that hydroxyaoatite nanoparticles are capable of enhancing the macroscopic stiffness at the structural level. To the contrary, Brillouin spectroscopy suggests that the microscopic elasticity of the nanocomposite was weakened.

Citation Download Citation

Zhaokai Meng, Chandani Chitrakar, Akhilesh K. Gaharwar, and Vladislav V. Yakovlev "Reinforcement of osteogenesis with nanofabricated hydroxyapatite and GelMA nanocomposite", Proc. SPIE 9303, Photonic Therapeutics and Diagnostics XI, 930340 (6 April 2015); https://doi.org/10.1117/12.2080301

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