Histology in vivo: chemical contrast combined with clinical multimodal multiphoton tomography

Martin Weinigel; Hans Georg Breunig; Karsten Koenig

doi:10.1117/12.2078307

5 March 2015 Histology in vivo: chemical contrast combined with clinical multimodal multiphoton tomography

Martin Weinigel, Hans Georg Breunig, Karsten Koenig

Proceedings Volume 9329, Multiphoton Microscopy in the Biomedical Sciences XV; 93291N (2015) https://doi.org/10.1117/12.2078307
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Label-free multiphoton tomography based on two-photon autofluorescence, fluorescence lifetime, and second harmonic generation imaging can be supplemented by coherent anti-Stokes Raman scattering. We present a compact, mobile and flexible clinical tomograph equipped with a novel detector design with multiple miniaturized detectors for individual acquisition of all four contrast mechanisms. Imaging of endogenous fluorophores, SHG-active collagen as well as nonfluorescent lipids in human skin in vivo is possible with this clinical tomograph paving the way towards in vivo histology.

Citation Download Citation

Martin Weinigel, Hans Georg Breunig, and Karsten Koenig "Histology in vivo: chemical contrast combined with clinical multimodal multiphoton tomography", Proc. SPIE 9329, Multiphoton Microscopy in the Biomedical Sciences XV, 93291N (5 March 2015); https://doi.org/10.1117/12.2078307

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KEYWORDS

Skin

In vivo imaging

Multiphoton tomography

Fluorescence lifetime imaging

Atrial fibrillation

Head

Imaging systems

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