Anticancer photodynamic therapy based on the use of a microsystem

E. Jastrzebska; N. Bulka; K. Zukowski; M. Chudy; Z. Brzozka; A. Dybko

doi:10.1117/12.2191503

17 July 2015 Anticancer photodynamic therapy based on the use of a microsystem

E. Jastrzebska, N. Bulka, K. Zukowski, M. Chudy, Z. Brzozka, A. Dybko

Author Affiliations +

Proceedings Volume 9540, Novel Biophotonics Techniques and Applications III; 95400X (2015) https://doi.org/10.1117/12.2191503
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

The paper presents the evaluation of photodynamic therapy (PDT) procedures with an application of a microsystem. Two cell lines were used in the experiments, i.e. human lung carcinoma - A549 and normal human fetal lung fibroblast MRC5. Mono-, coculture and mixed cultures were performed in a microsystem at the same time. The microsystem consisted of a concentration gradient generator (CGG) which generates different concentrations of a photosensitizer, and a set of microchambers for cells. The microchambers were linked by microchannels of various length in order to allow cells migration and in this way cocultures were created. Transparent materials were used for the chip manufacture, i.e. glass and poly(dimethylsiloxane). A high power LED was used to test photodynamic therapy effectiveness in the microsystem.

Citation Download Citation

E. Jastrzebska, N. Bulka, K. Zukowski, M. Chudy, Z. Brzozka, and A. Dybko "Anticancer photodynamic therapy based on the use of a microsystem ", Proc. SPIE 9540, Novel Biophotonics Techniques and Applications III, 95400X (17 July 2015); https://doi.org/10.1117/12.2191503

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