A creatinine biosensor based on admittance measurement

Congo Tak-Shing Ching; Tai-Ping Sun; Deng-Yun Jheng; Hou-Wei Tsai; Hsiu-Li Shieh

doi:10.1117/12.2187305

21 August 2015 A creatinine biosensor based on admittance measurement

Congo Tak-Shing Ching, Tai-Ping Sun, Deng-Yun Jheng, Hou-Wei Tsai, Hsiu-Li Shieh

Proceedings Volume 9550, Biosensing and Nanomedicine VIII; 95500N (2015) https://doi.org/10.1117/12.2187305
Event: SPIE Nanoscience + Engineering, 2015, San Diego, California, United States

Abstract

Regular check of blood creatinine level is very important as it is a measurement of renal function. Therefore, the objective of this study is to develop a simple and reliable creatinine biosensor based on admittance measurement for precise determination of creatinine. The creatinine biosensor was fabricated with creatinine deiminase immobilized on screen-printed carbon electrodes. Admittance measurement at a specific frequency ranges (22.80 - 84.71 Hz) showed that the biosensor has an excellent linear (r2 > 0.95) response range (50 - 250 uM), which covers the normal physiological and pathological ranges of blood creatinine levels. Intraclass correlation coefficient (ICC) showed that the biosensor has excellent reliability and validity (ICC = 0.98). In conclusion, a simple and reliable creatinine biosensor was developed and it is capable of precisely determining blood creatinine levels in both the normal physiological and pathological ranges.

Citation Download Citation

Congo Tak-Shing Ching, Tai-Ping Sun, Deng-Yun Jheng, Hou-Wei Tsai, and Hsiu-Li Shieh "A creatinine biosensor based on admittance measurement", Proc. SPIE 9550, Biosensing and Nanomedicine VIII, 95500N (21 August 2015); https://doi.org/10.1117/12.2187305

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