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15 March 2016 Enhanced second-harmonic-generation detection of collagen by means of optical wavefront shaping
Jonathan V. Thompson, Graham A. Throckmorton, Brett H. Hokr, Vladislav V. Yakovlev
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Proceedings Volume 9717, Adaptive Optics and Wavefront Control for Biological Systems II; 97170N (2016) https://doi.org/10.1117/12.2213644
Event: SPIE BiOS, 2016, San Francisco, California, United States
Abstract
Second-harmonic generation (SHG) has proven to be an effective method to both image and detect structural variations in fibrillar collagen. The ability to detect these differences is especially useful in studying diseases like cancer and fibrosis.1 SHG techniques have historically been limited by their ability to penetrate and image through strongly scattering tissues. Recently, optical wavefront shaping has enabled light to be focused through highly scattering media such as biological tissue.2-4 This technology also enables us to examine the dependence of second harmonic generation on the spatial phase of the pump laser. Here, we demonstrate that wavefront shaping can be used to enhance the generation of second harmonic light from collagen fibrils even when scattering is low or non-existent.
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Jonathan V. Thompson, Graham A. Throckmorton, Brett H. Hokr, and Vladislav V. Yakovlev "Enhanced second-harmonic-generation detection of collagen by means of optical wavefront shaping", Proc. SPIE 9717, Adaptive Optics and Wavefront Control for Biological Systems II, 97170N (15 March 2016); https://doi.org/10.1117/12.2213644
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KEYWORDS
Laser scattering
Nonlinear crystals
Signal detection
Optimization (mathematics)
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