Presentation
7 March 2022 Label-free histological imaging of skin cancers with photoacoustic remote sensing virtual histology
Author Affiliations +
Abstract
A Photoacoustic Remote Sensing (PARS) microscopy system is presented for label-free histological imaging of skin tissues. PARS captures label-free optical absorption contrast visualizing cell nuclei, connective tissues, lipids, and other structures with contrast analogous to common histochemical stains. Imaging is demonstrated in unprocessed human skin with basal cell carcinoma, squamous cell carcinoma, and melanoma. Visualizations are compared against traditional tissue preparation with histochemical staining. Preliminary clinical studies show comparable diagnostic quality between PARS histology and standard histology preparations. The proposed method is a milestone in this translational research project, aiming towards clinical deployment of a PARS microscope for skin cancer imaging.
Conference Presentation
© (2022) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Benjamin R. Ecclestone, Kevan Bell, Marian Boktor, Vladimir Pekar, Muba Taher, Deepak Dinakaran, John R. Mackey, and Parsin Haji Reza "Label-free histological imaging of skin cancers with photoacoustic remote sensing virtual histology", Proc. SPIE PC11934, Photonics in Dermatology and Plastic Surgery 2022, PC119340F (7 March 2022); https://doi.org/10.1117/12.2609176
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KEYWORDS
Skin cancer

Photoacoustic spectroscopy

Remote sensing

Tissues

Surgery

Skin

Tumors

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