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A scanning fiber endoscope system utilizing an alternative collection method for improved collection efficiency is presented. Low probability of two-photon excitation and high tissue scattering make signal collection a challenging aspect of two-photon imaging. Our work demonstrates a collection strategy using a high NA optical fiber bundle utilized in addition to the excitation fiber. This scheme significantly increases collection area without requiring collection optics at distal end. Experimentally determined collection efficiency of the method will be compared against our table-top two-photon microscope setup. Various effects of increased collection area on efficiency will be discussed with simulation results.
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Sertac G. Yazgi, Berk Camli, Liam P. Andrus, Adela Ben-Yakar, "An improved fluorescence collection method for two-photon imaging endoscopy," Proc. SPIE PC11937, Endoscopic Microscopy XVII, PC119370M (7 March 2022); https://doi.org/10.1117/12.2610023