In several retinal pathologies, such as AMD and retinitis pigmentosa, function of cones and rods are affected to different extents. To investigate these, an imaging modality is needed that separates the function of both photoreceptor types. Recently, functional imaging of single cones using phase-sensitive OCT has been demonstrated. However, until now, functional imaging of rods was only possible with high resolution systems. Here we differentiate the functional response of rods and cones without resolving single photoreceptors. After stimulation with short illumination in the mesoscopic range, the different temporal dynamics of rods and cones are distinguished by their typical response characteristics.
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