1Massachusetts Institute of Technology (United States) 2Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States) 3Wellman Ctr. for Photomedicine (United States)
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Polarization sensitivity is a powerful extension of conventional OCT, providing additional contrast for birefringent structures. However, its widespread clinical adoption is complicated by increased system complexity and cost. Single-input polarization-sensitive OCT provides an alternative which bypasses some of the hardware requirements but is prone to artifacts. Here we present a method utilizing existing polarization mode dispersion within the catheter in combination with optimization algorithms to accurately estimate the sample retardance. This strategy has been shown to suppress artifacts and improve agreement with conventional two-state PS-OCT, facilitating the clinical adoption using optimization methods to overcome hardware limitations.
Georgia Thomas,Brett Bouma, andMartin Villiger
"Improving single-input polarization-sensitive OCT using maximum likelihood estimation", Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC119481A (7 March 2022); https://doi.org/10.1117/12.2612413
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Georgia Thomas, Brett Bouma, Martin Villiger, "Improving single-input polarization-sensitive OCT using maximum likelihood estimation," Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC119481A (7 March 2022); https://doi.org/10.1117/12.2612413