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7 March 2022 All-optical forward-viewing photoacoustic remote sensing endoscope for high resolution label-free vascular imaging in vivo
Alkris Warren, Parsin Haji Reza
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Proceedings Volume PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022; PC119602K (2022) https://doi.org/10.1117/12.2608734
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
This work involves the development of a novel endoscope based on Photoacoustic Remote Sensing (PARS), for label-free in vivo imaging of microvasculature. The PARS endoscopy is realized by raster-scanning the proximal end of a coherent, image-guide fiber bundle containing 30,000 cores arranged within a 600-µm diameter image-circle. A graded-index (GRIN) distal-end objective lens is used to focus and collect the reflected probe beam. Based on preliminary results, the endoscope is measured to have a resolution of less than 3-µm. The developed PARS endoscope is characterized using phantoms and validated for in vivo application using a live chicken embryo model.
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Alkris Warren and Parsin Haji Reza "All-optical forward-viewing photoacoustic remote sensing endoscope for high resolution label-free vascular imaging in vivo", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119602K (7 March 2022); https://doi.org/10.1117/12.2608734
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KEYWORDS
Endoscopes
In vivo imaging
Photoacoustic spectroscopy
Remote sensing
Image resolution
Vascular imaging
Endoscopy
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