A framework for quantum-enhanced rare event detection in flow cytometry

Javier Sabines-Chesterking; Ivan A. Burenkov; Sergey V. Polyakov

doi:10.1117/12.2609768

9 March 2022 A framework for quantum-enhanced rare event detection in flow cytometry

Javier Sabines-Chesterking, Ivan A. Burenkov, Sergey V. Polyakov

Proceedings Volume PC12016, Optical and Quantum Sensing and Precision Metrology II; PC120161E (2022) https://doi.org/10.1117/12.2609768
Event: SPIE OPTO, 2022, San Francisco, California, United States

Abstract

Flow cytometry is the most common technique used to probe heterogeneous populations of cells in a high throughput manner. We are interested in the limit when (1) the occurrence of a specific target biomarker is rare and (2) biomarker concentration is low. Here we discuss a framework for in-situ characterizing signal noise levels in those systems, and the use of quantum measurement to optimize detection. Our method enables us to measure biomarker concentration and unambiguously identify the presence of a single emitter from first principles: i.e. without the need for auxiliary calibration.

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Javier Sabines-Chesterking, Ivan A. Burenkov, and Sergey V. Polyakov "A framework for quantum-enhanced rare event detection in flow cytometry", Proc. SPIE PC12016, Optical and Quantum Sensing and Precision Metrology II, PC120161E (9 March 2022); https://doi.org/10.1117/12.2609768

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KEYWORDS

Flow cytometry

Interference (communication)

Photons

Signal to noise ratio

Calibration

Pathogens

Single photon detectors

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