Handheld dual-axis confocal microscopy for neurosurgical guidance: Developing a 2nd-generation prototype

Kevin W. Bishop; Bingwen Hu; Adam K. Glaser; Nader Sanai M.D.; Jonathan T. C. Liu

doi:10.1117/12.2647997

17 March 2023 Handheld dual-axis confocal microscopy for neurosurgical guidance: Developing a 2nd-generation prototype

Kevin W. Bishop, Bingwen Hu, Adam K. Glaser, Nader Sanai M.D., Jonathan T. C. Liu

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Proceedings Volume PC12356, Endoscopic Microscopy XVIII; PC1235607 (2023) https://doi.org/10.1117/12.2647997
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The recent FDA approval of 5-aminolevulinic acid (5-ALA)/protoporphyrin IX (PpIX) for fluorescence-guided resection of gliomas has significantly improved surgeons’ ability to identify and remove bulk high-grade tumors using widefield imaging. However, the limited sensitivity of widefield fluorescence imaging makes it challenging to identify regions of sparse and low fluorophore accumulation, such as in low-grade gliomas and at the diffuse margins of all gliomas. Here we describe several improvements on a handheld confocal microscope designed to detect sparse PpIX fluorescence in vivo, with the goal of providing a quantitative method to guide glioma resections.

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Kevin W. Bishop, Bingwen Hu, Adam K. Glaser, Nader Sanai M.D., and Jonathan T. C. Liu "Handheld dual-axis confocal microscopy for neurosurgical guidance: Developing a 2nd-generation prototype", Proc. SPIE PC12356, Endoscopic Microscopy XVIII, PC1235607 (17 March 2023); https://doi.org/10.1117/12.2647997

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KEYWORDS

Confocal microscopy

Surgery

Prototyping

In vivo imaging

Signal detection

Luminescence

Tumors

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