CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC12359 > Article
Presentation
17 March 2023 Photodynamic approaches to alleviate desmoplasia: improving surgical and survival outcomes
Girgis Obaid, Chanda Bhandari, Shazia Bano, Kimberley Samkoe, Kenneth Hoyt, Tayyaba Hasan
Author Affiliations +
Proceedings Volume PC12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI; PC1235901 (2023) https://doi.org/10.1117/12.2644727
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Generally speaking, photodynamic therapy (PDT) for cancer has been viewed primarily as a therapeutic approach. In recent years, the integration of photodynamic therapy with secondary treatments has led to a deeper understanding of the sub-therapeutic photodynamic priming effects of PDT. In this work we show that stromal modulation by photodynamic priming of orthotopic head and neck tumors improved the tumor delivery and diagnostic accuracy of the clinical fluorescence image-guided surgery (IGS) probe Cetuximab-IRDye800CW (Cet-IRDye800) by 264.2%. We also explore the role of photodynamic priming in alleviating desmoplasia by reducing the density (>90%) and alignment (>10^3-fold) of collagen fibrillar networks in pancreatic tumors. In doing so, photodynamic priming using EGRF targeted multi-inhibitor liposomes containing irinotecan induced 90% tumor growth inhibition at only 8.1% of the patient equivalent dose of irinotecan, and double overall survival.
Conference Presentation
© (2023) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Girgis Obaid, Chanda Bhandari, Shazia Bano, Kimberley Samkoe, Kenneth Hoyt, and Tayyaba Hasan "Photodynamic approaches to alleviate desmoplasia: improving surgical and survival outcomes", Proc. SPIE PC12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI, PC1235901 (17 March 2023); https://doi.org/10.1117/12.2644727
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Photodynamic therapy
Tumors
Cancer
Collagen
Diagnostics
Head
Image-guided intervention
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top