Quantitative retinal blood flow measurement in humans using adaptive optics scanning laser ophthalmoscopy and erythrocyte mediated angiography

Achyut Raghavendra; Victoria Chen; Zhuolin Liu; Daniel X. Hammer; Osamah J. Saeedi

doi:10.1117/12.2651973

17 March 2023 Quantitative retinal blood flow measurement in humans using adaptive optics scanning laser ophthalmoscopy and erythrocyte mediated angiography

Achyut Raghavendra, Victoria Chen, Zhuolin Liu, Daniel X. Hammer, Osamah J. Saeedi

Author Affiliations +

Proceedings Volume PC12360, Ophthalmic Technologies XXXIII; PC1236005 (2023) https://doi.org/10.1117/12.2651973
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Although elevated intraocular pressure (IOP) is considered to be a major precursor for glaucoma, up to 45% of the patients with early glaucoma show signs of disease progression despite IOP reduction therapy. Studies have shown strong clinical evidence for abnormal ocular vessel function and impaired autoregulation of blood flow in early glaucoma subjects and its role in disease development and progression. Here we present direct measure of vascular dysfunction and autoregulation in three healthy human subjects using the erythrocyte mediate angiography and adaptive optics scanning laser ophthalmoscopy line-scan techniques. These novel quantitative blood flow metrics can potentially serve as a sensitive biomarker for early diagnosis and monitoring of ocular disease.

Conference Presentation

Citation Download Citation

Achyut Raghavendra, Victoria Chen, Zhuolin Liu, Daniel X. Hammer, and Osamah J. Saeedi "Quantitative retinal blood flow measurement in humans using adaptive optics scanning laser ophthalmoscopy and erythrocyte mediated angiography", Proc. SPIE PC12360, Ophthalmic Technologies XXXIII, PC1236005 (17 March 2023); https://doi.org/10.1117/12.2651973

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available