17 March 2023Structural metrics of the photoreceptor–pigment epithelium–choriocapillaris complex measured with 3.4 MHz adaptive optics–optical coherence tomography
Daniel X. Hammerhttps://orcid.org/0000-0003-0532-1914,1 Oliver Wolcott,1 Achyut Raghavendra,1 Zhuolin Liu,1 Samira Aghayee,2 Osamah J. Saeedi,3 Catherine A. Cukras4
1U.S. Food and Drug Administration (United States) 2Univ. of Maryland, College Park (United States) 3Univ. of Maryland School of Medicine (United States) 4National Eye Institute (United States)
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The photoreceptor (PR) – retinal pigment epithelium (RPE) – choriocapillaris (CC) complex is an extremely important group of layers in the outer retina. We demonstrate resolution of the CC vascular network across the macula, as well as the methodology to extract and quantify structural metrics from all three layers from averaged AO-OCT volumes. In diseased eyes, small changes in CC structure may portend the initiation of disease and therefore the investigation of CC structural changes may aid early disease diagnosis for many diseases, both prevalent and rare, that begin in the outer retina.
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Daniel X. Hammer, Oliver Wolcott, Achyut Raghavendra, Zhuolin Liu, Samira Aghayee, Osamah J. Saeedi, Catherine A. Cukras, "Structural metrics of the photoreceptor–pigment epithelium–choriocapillaris complex measured with 3.4 MHz adaptive optics–optical coherence tomography," Proc. SPIE PC12360, Ophthalmic Technologies XXXIII, PC123600G (17 March 2023); https://doi.org/10.1117/12.2650566