Wide-field 400-khz polarization diversity optical coherence tomography imaging of retinal pigment epithelium melanin loss in retinitis pigmentosa

Yusi Miao; Khaldon Abbas; Destiny Hsu; Jun Song; Hoyoung Jung; Eduardo V. Navajas; Myeong Jin Jin

doi:10.1117/12.2650439

17 March 2023 Wide-field 400-khz polarization diversity optical coherence tomography imaging of retinal pigment epithelium melanin loss in retinitis pigmentosa

Yusi Miao, Khaldon Abbas, Destiny Hsu, Jun Song, Hoyoung Jung, Eduardo V. Navajas, Myeong Jin Jin

Author Affiliations +

Proceedings Volume PC12360, Ophthalmic Technologies XXXIII; PC1236013 (2023) https://doi.org/10.1117/12.2650439
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Our research investigates retinal pigmentary abnormalities in retinitis pigmentosa (RP) patients using a wide-field high-speed polarization diversity optical coherence tomography (PD-OCT) in a clinical setting. To account for the retinal curvature in the wide field-of-view, adaptive kernel-based spatial averaging is employed for degree-of-polarization-uniformity (DOPU) contrast formation with two complex OCT signals from two orthogonal polarization channels. In 7 patients diagnosed with RP, retinal pigment epithelium (RPE) melanin loss centered at the macula is compared to standard multimodal imaging techniques, including intensity-based OCT, fundus photography, and short-wavelength fundus autofluorescence images.

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Citation Download Citation

Yusi Miao, Khaldon Abbas, Destiny Hsu, Jun Song, Hoyoung Jung, Eduardo V. Navajas, and Myeong Jin Jin "Wide-field 400-khz polarization diversity optical coherence tomography imaging of retinal pigment epithelium melanin loss in retinitis pigmentosa", Proc. SPIE PC12360, Ophthalmic Technologies XXXIII, PC1236013 (17 March 2023); https://doi.org/10.1117/12.2650439

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