Pathological changes in fiber structures in the eye detected with polarization-sensitive optical coherence tomography

Joy Willemse; Vincent S. Zoutenbier; Patrick González; Lucas J. Maillette de Buy Wenniger; Johannes F. de Boer

doi:10.1117/12.2648972

17 March 2023 Pathological changes in fiber structures in the eye detected with polarization-sensitive optical coherence tomography

Joy Willemse, Vincent S. Zoutenbier, Patrick González, Lucas J. Maillette de Buy Wenniger, Johannes F. de Boer

Author Affiliations +

Proceedings Volume PC12360, Ophthalmic Technologies XXXIII; PC1236014 (2023) https://doi.org/10.1117/12.2648972
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) is used to investigate changes in fiber structures in the eyes of myopia, wet age-related macular degeneration (wAMD), and glaucoma patients. A depth-multiplexed fiber-based PS-OCT system is used to extract local optic axis orientations of birefringent structures in the eye locally in 3D in vivo. For healthy volunteers, birefringent structures include the retinal nerves, Henle’s fiber layer, and sclera. Scleral collagen architecture is observed to be altered in myopia patients. In wAMD patients fibrosis orientation and volume can be extracted using this technique.

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Citation Download Citation

Joy Willemse, Vincent S. Zoutenbier, Patrick González, Lucas J. Maillette de Buy Wenniger, and Johannes F. de Boer "Pathological changes in fiber structures in the eye detected with polarization-sensitive optical coherence tomography", Proc. SPIE PC12360, Ophthalmic Technologies XXXIII, PC1236014 (17 March 2023); https://doi.org/10.1117/12.2648972

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