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17 March 2023 Clinical translation of near infrared nerve-specific fluorescence contrast agents for enhanced nerve identification during surgery
Connor W. Barth, Lei Wang, Antonio Montaño, Anas Masillati, Syed Rizvi, Adam Alani, Alexander Antaris, Jonathan Sorger, Summer Gibbs
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Proceedings Volume PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; PC123610J (2023) https://doi.org/10.1117/12.2651327
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Nerve damage ruins the lives of many patients post surgery, significantly affecting post-surgical quality of life. Intraoperative nerve detection is completed using anatomical knowledge and conventional white light visualization when possible. However, nerves can be difficult or impossible to identify by white light visualization and neuroanatomy is often varied between patients. We have developed nerve specific fluorescence guided surgery (FGS) contrast agents that provide real time direct visualization of nerves intraoperatively. These nerve-specific fluorophores represent the first of their kind and are capable of translation to clinical studies using existing clinical infrastructure of FGS systems. Work is underway to complete the preclinical pharmacology and toxicology testing required for a successful investigational new drug application to the FDA for first-in-human clinical trials and translation to surgical use should be feasible within the next five years.
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Connor W. Barth, Lei Wang, Antonio Montaño, Anas Masillati, Syed Rizvi, Adam Alani, Alexander Antaris, Jonathan Sorger, and Summer Gibbs "Clinical translation of near infrared nerve-specific fluorescence contrast agents for enhanced nerve identification during surgery", Proc. SPIE PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, PC123610J (17 March 2023); https://doi.org/10.1117/12.2651327
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KEYWORDS
Nerve
Surgery
Near infrared
Luminescence
Tissues
Visualization
Lead
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