Interferometric diffusing wave spectroscopy imaging with an electronically variable time-of-flight filter

Mingjun Zhao; Wenjun Zhou; Santosh Aparanji; Dibbyan Mazumder; Vivek Srinivasan

doi:10.1117/12.2649073

7 March 2023 Interferometric diffusing wave spectroscopy imaging with an electronically variable time-of-flight filter

Mingjun Zhao, Wenjun Zhou, Santosh Aparanji, Dibbyan Mazumder, Vivek Srinivasan

Proceedings Volume PC12376, Optical Tomography and Spectroscopy of Tissue XV; PC123760F (2023) https://doi.org/10.1117/12.2649073
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Interferometric DOS (iDOS) is a new class of approaches that promises to improve the quantitative accuracy and depth specificity of blood flow index (BFI). iDOS techniques have alternatively achieved either time-of-flight (TOF) discrimination or highly parallel detection, but not both at once. Here, we break this barrier with a single iDOS instrument. Specifically, we show that rapid tuning of a temporally coherent laser during the sensor integration time increases the effective linewidth seen by a highly parallel interferometer. With a deep TOF filter applied to a high throughput interferometer, we demonstrate brain-specific BFI imaging.

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Citation Download Citation

Mingjun Zhao, Wenjun Zhou, Santosh Aparanji, Dibbyan Mazumder, and Vivek Srinivasan "Interferometric diffusing wave spectroscopy imaging with an electronically variable time-of-flight filter", Proc. SPIE PC12376, Optical Tomography and Spectroscopy of Tissue XV, PC123760F (7 March 2023); https://doi.org/10.1117/12.2649073

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KEYWORDS

Spectroscopy

Interferometry

Imaging spectroscopy

Brain

Head

Light sources

Optical filters

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