Photoacoustic preclinical imaging study on tumor stroma quantification in breast cancer

Francis Kalloor Joseph; Tao Lu; Lena Heinrich; Jai Prakash; Wiendelt Steenbergen D.D.S.

doi:10.1117/12.2648240

9 March 2023 Photoacoustic preclinical imaging study on tumor stroma quantification in breast cancer

Francis Kalloor Joseph, Tao Lu, Lena Heinrich, Jai Prakash, Wiendelt Steenbergen D.D.S.

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123790R (2023) https://doi.org/10.1117/12.2648240
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Stromal cells play an active role in tumor proliferation, invasion, and metastasis. Fibroblast is a common stromal cell that aids in the production of collagen. Collagen accumulation in the tumor can result in squeezing blood vessels and reducing treatment efficiency. In this work, we present photoacoustic imaging of tumor stroma, analyzing the blood and collagen content. We imaged tumors from two small animal groups, one induced with tumor cells alone and another with tumor cells and fibroblast cells. Our results show significant differences in blood and collagen content in these two tumor types highlighting the effect of tumor stroma.

Conference Presentation

Citation Download Citation

Francis Kalloor Joseph, Tao Lu, Lena Heinrich, Jai Prakash, and Wiendelt Steenbergen D.D.S. "Photoacoustic preclinical imaging study on tumor stroma quantification in breast cancer", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123790R (9 March 2023); https://doi.org/10.1117/12.2648240

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