Label-free vasculature imaging using total absorption photoacoustic remote sensing

James A. Tummon Simmons; Sarah Werezak; Benjamin R. Ecclestone; Parsin Haji Reza; Nima Abbasi

doi:10.1117/12.2650196

9 March 2023 Label-free vasculature imaging using total absorption photoacoustic remote sensing

James A. Tummon Simmons, Sarah Werezak, Benjamin R. Ecclestone, Parsin Haji Reza, Nima Abbasi

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC1237913 (2023) https://doi.org/10.1117/12.2650196
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Detailed vasculature imaging is a critical tool for understanding tissue health especially for applications in cancer and ophthalmic diagnostics. Photoacoustic remote sensing (PARS), a novel imaging technology, has previously been successfully applied for both structural and functional imaging of vasculature including in dermatologic and ophthalmic imaging while remaining non-contact and label-free. To provide better molecular specificity, this work demonstrates a total-absorption PARS imaging system which incorporates sensitivity to both non-radiative and radiative contrast. This additional contrast enables more advanced molecular unmixing (e.g. between melanin, hemoglobin, and oxyhemoglobin) which will prove essential for all PARS vasculature imaging systems.

Conference Presentation

Citation Download Citation

James A. Tummon Simmons, Sarah Werezak, Benjamin R. Ecclestone, Parsin Haji Reza, and Nima Abbasi "Label-free vasculature imaging using total absorption photoacoustic remote sensing", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC1237913 (9 March 2023); https://doi.org/10.1117/12.2650196

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