CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC12583 > Article
Presentation
8 June 2023 Systematic in vivo experiments at the Dresden platform for ultrahigh dose rate radiobiology
Elke Beyreuther, Michael Brand, Steffen Loeck, Josefine Metzkes-Ng, Jörg Pawelke, Ulrich Schramm, Joao Seco, Rita E. Szabo, Karl Zeil
Author Affiliations +
Proceedings Volume PC12583, Applying Laser-driven Particle Acceleration III: Using Distinctive Energetic Particle and Photon Sources; PC1258305 (2023) https://doi.org/10.1117/12.2667906
Event: SPIE Optics + Optoelectronics, 2023, Prague, Czech Republic
Abstract
The abovementioned authors are named on behalf of their respective groups. The recent rediscovery of the “Flash Effect” revived the interest in high and ultra-high dose-rate radiation effects throughout the radiobiology community, promising protection of normal tissue, while simultaneously not altering tumour control. Systematic preclinical studies at (modified) clinical accelerators resulted in a recipe of necessary beam parameters for the induction of electron Flash effect (doi:10.3389/fonc.2019.01563), whereas for protons the optimal parameter setting is still under investigation. Expanding the clinical parameter range the “Dresden platform for high-dose rate radiobiology” enables electron and proton experiments with dose rates of up to 109 Gy/s and more flexible beam pulse structures. The general applicability of these beams for radiobiological studies was proven with zebrafish embryos a simple but robust normal tissue in vivo model. Overall, the analysis of the induced radiation effects reveal a clear normal tissue protecting Flash effect for ultra-high dose rate electron and proton beams relative to their conventional beam delivery.
Conference Presentation
© (2023) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Elke Beyreuther, Michael Brand, Steffen Loeck, Josefine Metzkes-Ng, Jörg Pawelke, Ulrich Schramm, Joao Seco, Rita E. Szabo, and Karl Zeil "Systematic in vivo experiments at the Dresden platform for ultrahigh dose rate radiobiology", Proc. SPIE PC12583, Applying Laser-driven Particle Acceleration III: Using Distinctive Energetic Particle and Photon Sources, PC1258305 (8 June 2023); https://doi.org/10.1117/12.2667906
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
;
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
In vivo imaging
Tissues
Radiation effects
Beam delivery
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top