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Multicellular tissues are a defining feature of animal life, but how tissue-level organization arises from the interactions of the individual proteins present at intercellular adhesion complexes remains incompletely understood. In this talk, I will describe single-molecule optical trap experiments that reveal the molecular mechanisms by which proteins present at cellular adhesion complexes help to seed long-range order in the cytoskeleton, and by extension, in multicellular tissues. These and other findings support an emerging understanding of how cells regulate cellular adhesion in space and time to generate tissues that are both dynamic and physically robust.
Alexander Dunn
"Symmetry breaking at cellular adhesion complexes", Proc. SPIE PC12649, Optical Trapping and Optical Micromanipulation XX, PC1264905 (5 October 2023); https://doi.org/10.1117/12.2682475
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Alexander Dunn, "Symmetry breaking at cellular adhesion complexes," Proc. SPIE PC12649, Optical Trapping and Optical Micromanipulation XX, PC1264905 (5 October 2023); https://doi.org/10.1117/12.2682475