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5 October 2023 Nanogap-enhanced biomolecular spectroscopies using plasmonic and dielectric nanostructures
Taka-aki Yano, Ryo Kato, Takuo Tanaka
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Proceedings Volume PC12654, Enhanced Spectroscopies and Nanoimaging 2023; PC126540B (2023) https://doi.org/10.1117/12.2678214
Event: SPIE Nanoscience + Engineering, 2023, San Diego, California, United States
Abstract
Field-enhanced biosensing has attracted considerable attention due to its capability of highly sensitive biomolecular detection and analysis. Here, we demonstrate a variety of nanogap-enhanced spectroscopies (fluorescence, Raman, infrared absorption) of biomolecular complexes using plasmonic and dielectric nanostructures. Plasmonic nanogaps between gold nanoparticles and gold nanoholes enabled us to perform plasmonic digital biosensing with the limit of detection (LOD) down to sub-fM level. All-dielectric nanogap antennas also allowed us for highly sensitive fluorescence immunosensing.
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Taka-aki Yano, Ryo Kato, and Takuo Tanaka "Nanogap-enhanced biomolecular spectroscopies using plasmonic and dielectric nanostructures", Proc. SPIE PC12654, Enhanced Spectroscopies and Nanoimaging 2023, PC126540B (5 October 2023); https://doi.org/10.1117/12.2678214
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KEYWORDS
Plasmonics
Biomolecules
Dielectrics
Nanostructures
Spectroscopy
Biosensing
Fluorescence
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