Imaging middle ear tissues with biofilms and cholesteatoma using polarization-sensitive swept-source optical coherence tomography

Adam Markowicz; Rishyashring R. Iyer; Kavya Sudhir; Guillermo L. Monroy; Darold R. Spillman Jr.; Stephen A. Boppart

doi:10.1117/12.3001909

13 March 2024 Imaging middle ear tissues with biofilms and cholesteatoma using polarization-sensitive swept-source optical coherence tomography

Adam Markowicz, Rishyashring R. Iyer, Kavya Sudhir, Guillermo L. Monroy, Darold R. Spillman Jr., Stephen A. Boppart

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Proceedings Volume PC12818, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2024; (2024) https://doi.org/10.1117/12.3001909
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Biofilms are persistent microbial communities that play a significant role in middle ear pathologies. Spectral domain (SD)-OCT has been used to detect biofilms in the middle ear during otitis media. However, it cannot measure birefringence or probe deeper regions of the middle ear cavity. A polarization-sensitive swept-source OCT system has been developed to image in vitro biofilms and cholesteatoma to enhance identification and classification of these pathologies. Biofilms were grown on tympanic membranes and ossicles to assess for changes in birefringence. A handheld probe is being developed to compare against a library of in vivo SD-OCT images.

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Adam Markowicz, Rishyashring R. Iyer, Kavya Sudhir, Guillermo L. Monroy, Darold R. Spillman Jr., and Stephen A. Boppart "Imaging middle ear tissues with biofilms and cholesteatoma using polarization-sensitive swept-source optical coherence tomography", Proc. SPIE PC12818, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2024, (13 March 2024); https://doi.org/10.1117/12.3001909

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KEYWORDS

Biofilms

Ear

Tissues

Optical coherence tomography

Birefringence

Pathology

In vitro testing

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