Dissolving microneedles (DMNs) is a non-invasive intradermal or systemic drug delivery system. Considering topical photodynamic therapy (PDT) for non-melanoma skin cancer treatment, limited cream permeation is one of the main issues. In this context, DMNs can improve the prodrugs permeation providing photosensitizer distribution within lesions. This study explored DMNs containing aminolevulinic acid (ALA) with Gantrez AN-139 considering manufacturing protocols, mechanical resistance, insertion capability, ALA distribution homogeneity, and performance in a human xenographic tumor model induced in balb/c mice.
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