Real-time SD-OCT guided photo-mediated ultrasound therapy of the retina

Mingyang Wang; Wei Zhang; Xinmai Yang; Xueding Wang; Yannis M. Paulus

doi:10.1117/12.3001011

13 March 2024 Real-time SD-OCT guided photo-mediated ultrasound therapy of the retina

Mingyang Wang, Wei Zhang, Xinmai Yang, Xueding Wang, Yannis M. Paulus

Proceedings Volume PC12824, Ophthalmic Technologies XXXIV; PC128241E (2024) https://doi.org/10.1117/12.3001011
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Photo-mediated ultrasound therapy (PUT) is a novel antivascular therapeutic modality based on cavitation-induced bioeffects. During PUT, concurrent, synchronized laser pulses and ultrasound bursts are used to selectively and precisely remove the targeted microvessels without harming nearby tissue. In our current study, an integrated system combining PUT and spectral domain optical coherence tomography (SD-OCT) was developed, where the SD-OCT system was used to guide PUT by detecting cavitation in real time in the retina of the eye. The performance of the integrated system in treatment of choroidal microvessels was examined. The capability of detecting cavitation on a vascular-mimicking phantom was evaluated along with rabbit eyes in vivo. The findings indicate real-time OCT monitoring can improve the safety and efficiency of PUT in removing the retinal and choroidal microvasculature.

Citation Download Citation

Mingyang Wang, Wei Zhang, Xinmai Yang, Xueding Wang, and Yannis M. Paulus "Real-time SD-OCT guided photo-mediated ultrasound therapy of the retina", Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC128241E (13 March 2024); https://doi.org/10.1117/12.3001011

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