Interferometric technique in speckle visibility spectroscopy (SVS) for blood flow decorrelation time measurements: advantages and limitations

Yu Xi Huang; Simon Mahler; Changhuei Yang

doi:10.1117/12.3008257

13 March 2024 Interferometric technique in speckle visibility spectroscopy (SVS) for blood flow decorrelation time measurements: advantages and limitations

Yu Xi Huang, Simon Mahler, Changhuei Yang

Author Affiliations +

Proceedings Volume PC12828, Neural Imaging and Sensing 2024; PC128280N (2024) https://doi.org/10.1117/12.3008257
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Diffusing Wave Spectroscopy (DWS) employs non-invasive techniques to study dynamic behaviors within scattering mediums. This involves detecting speckle light patterns from the moving media and gauging speckle decorrelation time for dynamic quantification. A specific form of DWS is Speckle Visibility Spectroscopy (SVS), which employs spatial ensembles by utilizing a high-pixel-count cameras to capture multiple speckles in a single frame. To further increase SNR at low signal level, one combines interferometric techniques with SVS to form interferometric SVS (iSVS). In this talk, I will present the benefits and constraints associated with the utilization of interferometric detection (iSVS) over direct detection (SVS). Surprisingly, we found that iSVS does not always outperform SVS, but it does emerge as the prevailing choice in most cases.

Conference Presentation

Citation Download Citation

Yu Xi Huang, Simon Mahler, and Changhuei Yang "Interferometric technique in speckle visibility spectroscopy (SVS) for blood flow decorrelation time measurements: advantages and limitations", Proc. SPIE PC12828, Neural Imaging and Sensing 2024, PC128280N (13 March 2024); https://doi.org/10.1117/12.3008257

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