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13 March 2024 SRS imaging of nanomedicine: one particle at a time
Wei Min
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Proceedings Volume PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry; PC128390J (2024) https://doi.org/10.1117/12.3009344
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Nanomedicine has brought significant advancements to healthcare by utilizing nanotechnology in medicine. Engineered nanoparticles, specifically nanocarriers, have the potential to overcome limitations of conventional drug delivery systems, improving solubility, circulation time, and transport across biological barriers. However, the development of nanocarriers for clinical use has been hindered by a lack of understanding of nano-bio interactions. Conventional imaging methods have limitations in resolution, sensitivity and specificity. Here we introduce stimulated Raman scattering (SRS) microscopy to image nanocarriers with single-particle sensitivity. We demonstrated quantitative analysis of nanocarrier biodistribution and degradation across different tissues including brain, This method provides a powerful tool for studying nanocarriers and quantitatively visualizing their distribution, interaction and clearance in vivo.
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Wei Min "SRS imaging of nanomedicine: one particle at a time", Proc. SPIE PC12839, Biomedical Vibrational Spectroscopy 2024: Advances in Research and Industry, PC128390J (13 March 2024); https://doi.org/10.1117/12.3009344
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KEYWORDS
Biological imaging
Microscopy
Nanomedicine
Medicine
Nanotechnology
Quantitative analysis
Raman scattering
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