Volumetric visualization and tracking of single bio-based indocyanine green (ICG) microcapsules

Yunbo Chen; Daniil Nozdriukhin; Sandra Michel-Souzy; Clemens Padberg; Lin Tang; Cagla Özsoy; Frederik Wurm; Daniel Razansky; Xosé Luís Deán-Ben; Olga Koshkina

doi:10.1117/12.3002950

13 March 2024 Volumetric visualization and tracking of single bio-based indocyanine green (ICG) microcapsules

Yunbo Chen, Daniil Nozdriukhin, Sandra Michel-Souzy, Clemens Padberg, Lin Tang, Cagla Özsoy, Frederik Wurm, Daniel Razansky, Xosé Luís Deán-Ben, Olga Koshkina

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Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC1284215 (2024) https://doi.org/10.1117/12.3002950
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Bio-compatible contrast agents based on clinically-approved indocyanine green (ICG) can greatly enhance the deep-tissue imaging performance of optoacoustic (OA) imaging systems and facilitate the clinical translation of this modality. In this work, we propose an inverse emulsion approach to synthetize bio-based, bio-degradable nano- and micro-capsules consisting of an aqueous core of ICG and a cross-linked casein shell. The feasibility to visualize and track individual capsules with a diameter of 4-5 micrometers is demonstrated in vitro and in vivo. This can pave the way towards clinical approval of contrast agents capable of being detected at a single-particle level.

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Yunbo Chen, Daniil Nozdriukhin, Sandra Michel-Souzy, Clemens Padberg, Lin Tang, Cagla Özsoy, Frederik Wurm, Daniel Razansky, Xosé Luís Deán-Ben, and Olga Koshkina "Volumetric visualization and tracking of single bio-based indocyanine green (ICG) microcapsules", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC1284215 (13 March 2024); https://doi.org/10.1117/12.3002950

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KEYWORDS

Indocyanine green

Visualization

Biomedical optics

Contrast agents

Emulsions

In vivo imaging

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