The state of folding of individual Amyloid-β oligomers in a lipid membrane correlates with their toxicity

Arpan Dey; Sudipta Maiti

doi:10.1117/12.3012974

13 March 2024 The state of folding of individual amyloid-β oligomers in a lipid membrane correlates with their toxicity

Arpan Dey, Sudipta Maiti

Author Affiliations +

Proceedings Volume PC12849, Single Molecule Spectroscopy and Superresolution Imaging XVII; PC1284908 (2024) https://doi.org/10.1117/12.3012974
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Oligomers of disease-causing amyloid proteins (such as Alzheimer’s Amyloid beta or ’Aβ’) are generally amphiphilic and their interactions with lipid membranes are possibly the origin of their toxicity. However, how oligomers of different stoichiometries or different mutants differ in their interaction with the membrane, and how these differences correlate with their toxicity, has largely remained beyond the reach of existing experimental techniques. Here we use Q-SLIP, a single-molecule tool that can resolve the surface exposure of different parts of individual oligomers, and different radical-labeled lipids that act as quenchers, to address these questions.

Conference Presentation

Citation Download Citation

Arpan Dey and Sudipta Maiti "The state of folding of individual amyloid-β oligomers in a lipid membrane correlates with their toxicity", Proc. SPIE PC12849, Single Molecule Spectroscopy and Superresolution Imaging XVII, PC1284908 (13 March 2024); https://doi.org/10.1117/12.3012974

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE