CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 12 > Issue 2 > Article
Open Access
1 March 2007 Mid-infrared laser measurements of aqueous glucose
Bujin Guo, Yi Wang, Yang Wang, Han Q. Le
Author Affiliations +
Journal of Biomedical Optics, Vol. 12, Issue 2, 024005 (March 2007). https://doi.org/10.1117/1.2714283
Abstract
Mid-IR semiconductor lasers of two wavelength bands, 5.4 and 9.6 μm, are applied to measure aqueous glucose concentration ranging from 0 to 500 mg/dL with Intralipid® emulsion (0 to 8%) added as a fat simulator. The absorption coefficient µa is found linear with respect to glucose and Intralipid® concentrations, and their specific absorption coefficients are obtained via linear regression. These coefficients are subsequently used to infer the concentrations and compare with known values. The objective is to evaluate the method accuracy. Glucose concentration is determined within ±21 mg/dL with 90% confidence and ±32 mg/dL with 99% confidence, using <1-mJ laser energy. It is limited by the apparatus mechanical error and not the photometric system noise. The expected uncertainties due to photometric noise are ±6 and ±9 mg/dL with 90 and 99% confidence, respectively. The uncertainty is fully accounted for by the system intrinsic errors, allowing rigorous inference of the confidence level. Intralipid® is found to have no measurable effect on glucose determination. Further analysis suggests that a few mid-IR wavelengths may be sufficient, and that the laser technique offers advantages with regard to accuracy, speed, and sample volume, which can be small, ~0.4×10-7 mL for applications such as microfluidic or microbioarray monitoring.
©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Bujin Guo, Yi Wang, Yang Wang, and Han Q. Le "Mid-infrared laser measurements of aqueous glucose," Journal of Biomedical Optics 12(2), 024005 (1 March 2007). https://doi.org/10.1117/1.2714283
Published: 1 March 2007
JOURNAL ARTICLE
 14 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 5 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Glucose
Absorption
Mid-IR
Calibration
Semiconductor lasers
Transmittance
Blood
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top