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1 November 2007 Core-shell silica nanoparticles as fluorescent labels for nanomedicine
Jinhyang Choi, Andrew A. Burns, Rebecca M. Williams, Zongziang Zhou, Andrea Flesken-Nikitin, Warren R. Zipfel, Ulrich Wiesner, Alexander Yu Nikitin
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Journal of Biomedical Optics, Vol. 12, Issue 6, 064007 (November 2007). https://doi.org/10.1117/1.2823149
Abstract
Progress in biomedical imaging depends on the development of probes that combine low toxicity with high sensitivity, resolution, and stability. Toward that end, a new class of highly fluorescent core-shell silica nanoparticles with narrow size distributions and enhanced photostability, known as C dots, provide an appealing alternative to quantum dots. Here, C dots are evaluated with a particular emphasis on in-vivo applications in cancer biology. It is established that C dots are nontoxic at biologically relevant concentrations, and can be used in a broad range of imaging applications including intravital visualization of capillaries and macrophages, sentinel lymph node mapping, and peptide-mediated multicolor cell labeling for real-time imaging of tumor metastasis and tracking of injected bone marrow cells in mice. These results demonstrate that fluorescent core-shell silica nanoparticles represent a powerful novel imaging tool within the emerging field of nanomedicine.
©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Jinhyang Choi, Andrew A. Burns, Rebecca M. Williams, Zongziang Zhou, Andrea Flesken-Nikitin, Warren R. Zipfel, Ulrich Wiesner, and Alexander Yu Nikitin "Core-shell silica nanoparticles as fluorescent labels for nanomedicine," Journal of Biomedical Optics 12(6), 064007 (1 November 2007). https://doi.org/10.1117/1.2823149
Published: 1 November 2007
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Cited by 118 scholarly publications and 3 patents.
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KEYWORDS
Particles
Silica
Nanoparticles
Bone
Luminescence
In vivo imaging
Lymphatic system
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