Characterization of tumor microvascular structure and permeability: comparison between magnetic resonance imaging and intravital confocal imaging

Nina K. Reitan; Marte Thuen; Pål Erik Goa; Catharina de Lange Davies

doi:10.1117/1.3431095

1 May 2010 Characterization of tumor microvascular structure and permeability: comparison between magnetic resonance imaging and intravital confocal imaging

Nina K. Reitan, Marte Thuen, Pål Erik Goa, Catharina de Lange Davies

Author Affiliations +

Journal of Biomedical Optics, Vol. 15, Issue 3, 036004 (May 2010). https://doi.org/10.1117/1.3431095

Abstract

Solid tumors are characterized by abnormal blood vessel organization, structure, and function. These abnormalities give rise to enhanced vascular permeability and may predict therapeutic responses. The permeability and architecture of the microvasculature in human osteosarcoma tumors growing in dorsal window chambers in athymic mice were measured by confocal laser scanning microscopy (CLSM) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Dextran (40 kDa) and Gadomer were used as molecular tracers for CLSM and DCE-MRI, respectively. A significant correlation was found between permeability indicators. The extravasation rate K_i as measured by CLSM correlated positively with DCE-MRI parameters, such as the volume transfer constant K^trans and the initial slope of the contrast agent concentration-time curve. This demonstrates that these two techniques give complementary information. Extravasation was further related to microvascular structure and was found to correlate with the fractal dimension and vascular density. The structural parameter values that were obtained from CLSM images were higher for abnormal tumor vasculature than for normal vessels.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Nina K. Reitan, Marte Thuen, Pål Erik Goa, and Catharina de Lange Davies "Characterization of tumor microvascular structure and permeability: comparison between magnetic resonance imaging and intravital confocal imaging," Journal of Biomedical Optics 15(3), 036004 (1 May 2010). https://doi.org/10.1117/1.3431095

Published: 1 May 2010

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KEYWORDS

Tumors

Tissues

Magnetic resonance imaging

Blood vessels

Fractal analysis

Luminescence

Plasma

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