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1 November 2011 High-resolution imaging diagnosis of human fetal membrane by three-dimensional optical coherence tomography
Hugang Ren, Cecilia Avila, Cynthia Kaplan
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Journal of Biomedical Optics, Vol. 16, Issue 11, 116006 (November 2011). https://doi.org/10.1117/1.3646530
Abstract
Microscopic chorionic pseudocyst (MCP) arising in the chorion leave of the human fetal membrane (FM) is a clinical precursor for preeclampsia which may progress to fatal medical conditions (e.g., abortion) if left untreated. To examine the utility of three-dimensional (3D) optical coherence tomography (OCT) for noninvasive delineation of the morphology of human fetal membranes and early clinical detection of MCP, 60 human FM specimens were acquired from 10 different subjects undergoing term cesarean delivery for an ex vivo feasibility study. Our results showed that OCT was able to identify the four-layer architectures of human FMs consisting of high-scattering decidua vera (DV, average thickness dDV ≈ 92±38 μm), low-scattering chorion and trophoblast (CT, dCT ≈ 150±67 μm), high-scattering subepithelial amnion (A, dA ≈ 95±36 μm), and low-scattering epithelium (E, dE ≈ 29±8 μm). Importantly, 3D OCT was able to instantaneously detect MCPs (low scattering due to edema, fluid buildup, vasodilatation) and track (staging) their thicknesses dMCP ranging from 24 to 615 μm. It was also shown that high-frequency ultrasound was able to compliment OCT for detecting more advanced thicker MCPs (e.g., dMCP<615 μm) because of its increased imaging depth.
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2011/16(11)/116006/6/$25.00
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Hugang Ren, Cecilia Avila, and Cynthia Kaplan "High-resolution imaging diagnosis of human fetal membrane by three-dimensional optical coherence tomography," Journal of Biomedical Optics 16(11), 116006 (1 November 2011). https://doi.org/10.1117/1.3646530
Published: 1 November 2011
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KEYWORDS
Optical coherence tomography
Microchannel plates
Fermium
3D image processing
Image segmentation
Fetus
Frequency modulation
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