Simultaneous fluorescence and positron emission tomography for in vivo imaging of small animals

Bin Zhang; Fei Liu; Yanyan Xu; Jing Bai; Shuangquan Liu; Baoci Shan; Xiaochun Zhang; Jianwen Luo

doi:10.1117/1.3665438

1 December 2011 Simultaneous fluorescence and positron emission tomography for in vivo imaging of small animals

Bin Zhang, Fei Liu, Yanyan Xu, Jing Bai, Shuangquan Liu, Baoci Shan, Xiaochun Zhang, Jianwen Luo

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Journal of Biomedical Optics, Vol. 16, Issue 12, 120511 (December 2011). https://doi.org/10.1117/1.3665438

Abstract

Simultaneous positron emission tomography (PET) and fluorescence tomography (FT) for in vivo imaging of small animals is proposed by a dual-modality system. This system combines a charge-coupled device-based near-infrared fluorescence imaging with a planar detector pair-based PET. With [¹⁸F]-2-fluoro-2-deoxy-d-glucose radioactive tracer and the protease activated fluorescence probe, on the one hand, the simultaneous metabolic activity and protease activity in tumor region are revealed by the PET and FT, respectively. On the other hand, the protease activity both on the surface layer and the deep tissue of the tumor is provided by the fluorescence reflection imaging and FT, respectively.

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Bin Zhang, Fei Liu, Yanyan Xu, Jing Bai, Shuangquan Liu, Baoci Shan, Xiaochun Zhang, and Jianwen Luo "Simultaneous fluorescence and positron emission tomography for in vivo imaging of small animals," Journal of Biomedical Optics 16(12), 120511 (1 December 2011). https://doi.org/10.1117/1.3665438

Published: 1 December 2011

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