Correlation of within-individual fluctuation of depressed mood with prefrontal cortex activity during verbal working memory task: optical topography study

Hiroki Sato; Takusige Katura; Hideaki Koizumi; Ryuta Aoki; Ryoichi Matsuda

doi:10.1117/1.3662448

1 December 2011 Correlation of within-individual fluctuation of depressed mood with prefrontal cortex activity during verbal working memory task: optical topography study

Hiroki Sato, Takusige Katura, Hideaki Koizumi, Ryuta Aoki, Ryoichi Matsuda

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Journal of Biomedical Optics, Vol. 16, Issue 12, 126007 (December 2011). https://doi.org/10.1117/1.3662448

Abstract

Previous studies showed that interindividual variations in mood state are associated with prefrontal cortex (PFC) activity. In this study, we focused on the depressed-mood state under natural circumstances and examined the relationship between within-individual changes over time in this mood state and PFC activity. We used optical topography (OT), a functional imaging technique based on near-infrared spectroscopy, to measure PFC activity for each participant in three experimental sessions repeated at 2-week intervals. In each session, the participants completed a self-report questionnaire of mood state and underwent OT measurement while performing verbal and spatial working memory (WM) tasks. The results showed that changes in the depressed-mood score between successive sessions were negatively correlated with those in the left PFC activation for the verbal WM task (ρ = −0.56, p < 0.05). In contrast, the PFC activation for the spatial WM task did not co-vary with participants' mood changes. We thus demonstrated that PFC activity during a verbal WM task varies depending on the participant's depressed mood state, independent of trait factors. This suggests that using optical topography to measure PFC activity during a verbal WM task can be used as a potential state marker for an individual's depressed mood state.

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Hiroki Sato, Takusige Katura, Hideaki Koizumi, Ryuta Aoki, and Ryoichi Matsuda "Correlation of within-individual fluctuation of depressed mood with prefrontal cortex activity during verbal working memory task: optical topography study," Journal of Biomedical Optics 16(12), 126007 (1 December 2011). https://doi.org/10.1117/1.3662448

Published: 1 December 2011

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