Quantitative estimation of mechanical and optical properties from ultrasound assisted optical tomography data

Mayanglambam S. Singh; Kanhirodan Rajan; Ram M. Vasu; Debasish Roy

doi:10.1117/1.JBO.17.10.101507

22 June 2012 Quantitative estimation of mechanical and optical properties from ultrasound assisted optical tomography data

Mayanglambam S. Singh, Kanhirodan Rajan, Ram M. Vasu, Debasish Roy

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Journal of Biomedical Optics, Vol. 17, Issue 10, 101507 (June 2012). https://doi.org/10.1117/1.JBO.17.10.101507

Abstract

We demonstrate quantitative optical property and elastic property imaging from ultrasound assisted optical tomography data. The measurements, which are modulation depth M and phase ϕ of the speckle pattern, are shown to be sensitively dependent on these properties of the object in the insonified focal region of the ultrasound (US) transducer. We demonstrate that Young's modulus (E) can be recovered from the resonance observed in M versus ω (the US frequency) plots and optical absorption (μa) and scattering (μs) coefficients from the measured differential phase changes. All experimental observations are verified also using Monte Carlo simulations.

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Mayanglambam S. Singh, Kanhirodan Rajan, Ram M. Vasu, and Debasish Roy "Quantitative estimation of mechanical and optical properties from ultrasound assisted optical tomography data," Journal of Biomedical Optics 17(10), 101507 (22 June 2012). https://doi.org/10.1117/1.JBO.17.10.101507

Published: 22 June 2012

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