Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasound

Julien Bec; Hongtao Xie; Diego R. Yankelevich; Feifei Zhou; Yang Sun; Narugopal Ghata; Ralph C. Aldredge; Laura Marcu

doi:10.1117/1.JBO.17.10.106012

1 October 2012 Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasound

Julien Bec, Hongtao Xie, Diego R. Yankelevich, Feifei Zhou, Yang Sun, Narugopal Ghata, Ralph C. Aldredge, Laura Marcu

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Journal of Biomedical Optics, Vol. 17, Issue 10, 106012 (October 2012). https://doi.org/10.1117/1.JBO.17.10.106012

Abstract

We report the development and validation of an intravascular rotary catheter for bimodal interrogation of arterial pathologies. This is based on a point-spectroscopy scanning time-resolved fluorescence spectroscopy technique enabling reconstruction of fluorescence lifetime images (FLIm) and providing information on arterial intima composition and intravascular ultrasound (IVUS) providing information on arterial wall morphology. The catheter design allows for independent rotation of the ultrasonic and optical channels within an 8 Fr outer diameter catheter sheath and integrates a low volume flushing channel for blood removal in the optical pathways. In the current configuration, the two channels consist of (a) a standard 3 Fr IVUS catheter with single element transducer (40 MHz) and (b) a side-viewing fiber optic (400 μm core). Experiments conducted in tissue phantoms showed the ability of the catheter to operate in an intraluminal setting and to generate coregistered FLIm and IVUS in one pull-back scan. Current results demonstrate the feasibility of the catheter for simultaneous bimodal interrogation of arterial lumen and for generation of robust fluorescence lifetime data under IVUS guidance. These results facilitate further development of a FLIm-IVUS technique for intravascular diagnosis of atherosclerotic cardiovascular diseases including vulnerable plaques.

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Julien Bec, Hongtao Xie, Diego R. Yankelevich, Feifei Zhou, Yang Sun, Narugopal Ghata, Ralph C. Aldredge, and Laura Marcu "Design, construction, and validation of a rotary multifunctional intravascular diagnostic catheter combining multispectral fluorescence lifetime imaging and intravascular ultrasound," Journal of Biomedical Optics 17(10), 106012 (1 October 2012). https://doi.org/10.1117/1.JBO.17.10.106012

Published: 1 October 2012

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