Comparison of Schlemm's canal's biological parameters in primary open-angle glaucoma and normal human eyes with swept source optical

Fei Wang; Guohua Shi; Xiqi Li; Jing Lu; Zhihua Ding; Xinghuai Sun; Chunhui Jiang; Yudong Zhang

doi:10.1117/1.JBO.17.11.116008

1 November 2012 Comparison of Schlemm's canal's biological parameters in primary open-angle glaucoma and normal human eyes with swept source optical

Fei Wang, Guohua Shi, Xiqi Li, Jing Lu, Zhihua Ding, Xinghuai Sun, Chunhui Jiang, Yudong Zhang

Author Affiliations +

Funded by: National Science Foundation of China, Chinese Academy of Sciences, Knowledge Innovation Program of the Chinese Academy of Sciences, Research Foundation of Fudan University

Journal of Biomedical Optics, Vol. 17, Issue 11, 116008 (November 2012). https://doi.org/10.1117/1.JBO.17.11.116008

Abstract

Thirty-seven normal and primary open angle glaucoma (POAG) subjects were noninvasively imaged by a tailor-made real-time anterior segment swept source optical coherence tomography (SS-OCT) to demonstrate the differences of the Schlemm's canal (SC) between POAG and normal eyes. After the cross-section images of the anterior chamber angle were acquired by SS-OCT, SC was confirmed by two independent masked observers and the average area, long diameter, and perimeter of the SC were measured. In normal subjects the circumference, area, and long diameter is <b<508.34±87.81 μm</b<, <b<8023.89±1486.10 μm²</b<, and <b<272.83±49.39 μm</b<, respectively, and these parameters were <b<393.25±98.04 μm</b<, <b<3941.50±1210.69 μm²</b<, and <b<190.91±46.47 μm</b< in the POAG subjects. The area of SC in the normal ones was significantly larger than that in POAG eyes (<b<p<0.001</b<), so as the long diameter and the perimeter (<b<p<0.001</b<; <b<p<0.001</b<).

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Fei Wang, Guohua Shi, Xiqi Li, Jing Lu, Zhihua Ding, Xinghuai Sun, Chunhui Jiang, and Yudong Zhang "Comparison of Schlemm's canal's biological parameters in primary open-angle glaucoma and normal human eyes with swept source optical," Journal of Biomedical Optics 17(11), 116008 (1 November 2012). https://doi.org/10.1117/1.JBO.17.11.116008

Published: 1 November 2012

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