Monitoring of tumor response to cisplatin by subsurface fluorescence molecular tomography

Fei Liu; Xu Cao; Wei He; Jinping Song; Zhongquan Dai; Bin Zhang; Jianwen Luo; Jing Bai; Yinghui Li

doi:10.1117/1.JBO.17.4.040504

6 April 2012 Monitoring of tumor response to cisplatin by subsurface fluorescence molecular tomography

Fei Liu, Xu Cao, Wei He, Jinping Song, Zhongquan Dai, Bin Zhang, Jianwen Luo, Jing Bai, Yinghui Li

Author Affiliations +

Journal of Biomedical Optics, Vol. 17, Issue 4, 040504 (April 2012). https://doi.org/10.1117/1.JBO.17.4.040504

Abstract

Subsurface fluorescence molecular tomography (FMT) has promising potential for noninvasive characterization of molecular and cellular activities in small animals by tomographic means in reflectance geometry. In this work, subsurface FMT is employed to monitor the therapeutic response of cisplatin in tumor-bearing mice in vivo. The localization and quantification accuracy of subsurface FMT are demonstrated in phantom. In the in vivo study, the red fluorescent protein activities not only on the surface but in the interior tumor are tracked three-dimensionally during the antitumor treatment.

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Fei Liu, Xu Cao, Wei He, Jinping Song, Zhongquan Dai, Bin Zhang, Jianwen Luo, Jing Bai, and Yinghui Li "Monitoring of tumor response to cisplatin by subsurface fluorescence molecular tomography," Journal of Biomedical Optics 17(4), 040504 (6 April 2012). https://doi.org/10.1117/1.JBO.17.4.040504

Published: 6 April 2012

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