Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner

Shanshan Liang; Changsen Sun; Arya Saidi; Joseph Jing; Gangjun Liu; Jiawen Li; Jun Zhang; Zhongping Chen; Jagat Narula M.D.

doi:10.1117/1.JBO.17.7.070501

28 June 2012 Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner

Shanshan Liang, Changsen Sun, Arya Saidi, Joseph Jing, Gangjun Liu, Jiawen Li, Jun Zhang, Zhongping Chen, Jagat Narula M.D.

Author Affiliations +

Funded by: National Institutes of Health, NIH, Air Force Office of Scientific Research (AFOSR), AFOSR, Military Photomedicine Program, Military Photomedicine Program, AFOSR, National Institute of Environmental Health Sciences (NIEHS), Military Medical Photonics Program, AFOSR, NSF IGERT, Air Force Office of Scientific Research Medical Free-Electron Laser Program

Journal of Biomedical Optics, Vol. 17, Issue 7, 070501 (June 2012). https://doi.org/10.1117/1.JBO.17.7.070501

Abstract

We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as image display. For fluorescence imaging, the inflammation of atherosclerosis and necrotic core formed with the annexin V-conjugated Cy5.5 were imaged. Ex vivo imaging of New Zealand white rabbit arteries demonstrated the capability of the combined system.

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Shanshan Liang, Changsen Sun, Arya Saidi, Joseph Jing, Gangjun Liu, Jiawen Li, Jun Zhang, Zhongping Chen, and Jagat Narula M.D. "Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner," Journal of Biomedical Optics 17(7), 070501 (28 June 2012). https://doi.org/10.1117/1.JBO.17.7.070501

Published: 28 June 2012

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