Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

Richard A. Wall; Jennifer K. Barton

doi:10.1117/1.JBO.17.8.086003

3 August 2012 Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope

Richard A. Wall, Jennifer K. Barton

Author Affiliations +

Journal of Biomedical Optics, Vol. 17, Issue 8, 086003 (August 2012). https://doi.org/10.1117/1.JBO.17.8.086003

Abstract

A side-viewing, 2.3-mm diameter, surface magnifying chromoendoscopy-optical coherence tomography (SMC-OCT) endoscope has been designed for simultaneous, nondestructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of the mouse colon. A 30,000 element fiber bundle is combined with single mode fibers, for SMC and OCT imaging, respectively. The distal optics consist of a gradient-index lens and spacer to provide a 1× magnification at a working distance of 1.58 mm in air, necessary to image the sample through a 0.23-mm thick outer glass envelope, and an aluminized right-angle prism fixed to the distal end of the gradient-index lens assembly. The resulting 1∶1 imaging system is capable of 3.9-µm lateral and 2.3-µm axial resolution in the OCT channel, and 125-lp/mm resolution across a 0.70-mm field of view in the SMC channel. The endoscope can perform high contrast crypt visualization, molecular imaging, and cross-sectional imaging of colon microstructure.

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Richard A. Wall and Jennifer K. Barton "Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope," Journal of Biomedical Optics 17(8), 086003 (3 August 2012). https://doi.org/10.1117/1.JBO.17.8.086003

Published: 3 August 2012

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Cited by 20 scholarly publications and 1 patent.

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KEYWORDS

Optical coherence tomography

Colon

Endoscopes

GRIN lenses

Image resolution

Imaging systems

Tissues

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