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27 January 2014 Temperature elevation profile inside the rat brain induced by a laser beam
Ali Ersen, Ammar Abdo, Mesut Sahin
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Journal of Biomedical Optics, Vol. 19, Issue 1, 015009 (January 2014). https://doi.org/10.1117/1.JBO.19.1.015009
Abstract
The thermal effect may be a desired outcome or a concerning side effect in laser–tissue interactions. Research in this area is particularly motivated by recent advances in laser applications in diagnosis and treatment of neurological disorders. Temperature as a side effect also limits the maximum power of optical transfer and harvesting of energy in implantable neural prostheses. The main objective was to investigate the thermal effect of a near-infrared laser beam directly aimed at the brain cortex. A small, custom-made thermal probe was inserted into the rat brain to make direct measurements of temperature elevations induced by a free-air circular laser beam. The time dependence and the spatial distribution of the temperature increases were studied and the maximum allowable optical power was determined to be 2.27  W/cm2 for a corresponding temperature increase of 0.5°C near the cortical surface. The results can be extrapolated for other temperature elevations, where the margin to reach potentially damaging temperatures is more relaxed, by taking advantage of linearity. It is concluded that the thermal effect depends on several factors such as the thermal properties of the neural tissue and of its surrounding structures, the optical properties of the particular neural tissue, and the laser beam size and shape. Because so many parameters play a role, the thermal effect should be investigated for each specific application separately using realistic in vivo models.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Ali Ersen, Ammar Abdo, and Mesut Sahin "Temperature elevation profile inside the rat brain induced by a laser beam," Journal of Biomedical Optics 19(1), 015009 (27 January 2014). https://doi.org/10.1117/1.JBO.19.1.015009
Published: 27 January 2014
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Cited by 12 scholarly publications and 1 patent.
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KEYWORDS
Temperature metrology
Brain
Laser tissue interaction
Tissue optics
Near infrared
Thermal effects
Laser therapeutics
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